This study made me curious and I spent a few minutes searching for over-the-counter medications we actually put in our bodies. You always check the back of that bottle of lotion for ingredients, but do you check your suppositories?
Preparation H should be called "Preparation Paraben". Those little suppositories contain both methylparaben and propylparaben.
Children's Tylenol Liquid Contains Butylparaben.
- Parabens are used in some medications and may adversely affect reproduction
- We compare urinary paraben concentrations in relation to medication use
- We control for use of personal care products, an important exposure source
- Paraben-containing medications were associated with increased urinary concentrations
- Paraben-containing medications can be a source of very high paraben exposure
Determine whether paraben-containing medication contributes to high urinary paraben concentrations.
Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-hour use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples “exposed” and “unexposed” to paraben-containing medication.
Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within seven hours was associated with 8.7-fold and 7.5-fold increases in mean methyl (P=0.11) and propyl (P=0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P=0.76) and 2.6-fold (P=0.34), respectively, after removal of one influential individual.
Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.